Intermittent Hypoxia, Sleep Fragmentation and Glucose Tolerance
نویسندگان
چکیده
منابع مشابه
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives.
There are three major types of sleep-disordered breathing (SDB) with respect to prevalence and health consequences, i.e. obstructive sleep apnoea syndrome (OSAS), Cheyne-Stokes respiration and central sleep apnoea (CSR-CSA) in chronic heart failure, and obesity hypoventilation syndrome (OHS). In all three conditions, hypoxia appears to affect body functioning in different ways. Most of the mole...
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In this study, we investigated the influence of depth and duration of intermittent hypoxia (IH) on the infarct size development in isolated rat heart. The role of nitric oxide synthase (NOS) and ATP-sensitive K+ (K(ATP)) channel was also studied. Wistar male rats were exposed to IH [repetitive cycles of 1 min, 40 s with inspired oxygen fraction (FI(O2)), 5 or 10%, followed by 20-s normoxia], du...
متن کاملImpaired Glucose Tolerance in Sleep Disorders
BACKGROUND Recent epidemiological and experimental data suggest a negative influence of shortened or disturbed night sleep on glucose tolerance. Due to the high prevalence of sleep disorders this might be a major health issue. However, no comparative studies of carbohydrate metabolism have been conducted in clinical sleep disorders. METHODOLOGY/PRINCIPAL FINDINGS We performed oral glucose tol...
متن کاملPhysiological and Genomic Consequences of Intermittent Hypoxia Selected Contribution: Improved anoxic tolerance in rat diaphragm following intermittent hypoxia
THOMAS L. CLANTON1, VALERIE P. WRIGHT1, PETER J. REISER2, PAUL F. KLAWITTER3, AND NANDURI R. PRABHAKAR4 1Department of Internal Medicine, Pulmonary and Critical Care Medicine, The Dorothy Davis Heart and Lung Research Institute, 2Department of Oral Biology, College of Dentistry, and the 3Department of Emergency Medicine, The Ohio State University, Columbus, Ohio 43210; and 4Department of Physio...
متن کاملChronic and intermittent hypoxia induce different degrees of myocardial tolerance to hypoxia-induced dysfunction.
Chronic hypoxia (CH) is believed to induce myocardial protection, but this is in contrast with clinical evidence. Here, we test the hypothesis that repeated brief reoxygenation episodes during prolonged CH improve myocardial tolerance to hypoxia-induced dysfunction. Male 5-week-old Sprague-Dawley rats (n = 7-9/group) were exposed for 2 weeks to CH (F(I)O(2) = 0.10), intermittent hypoxia (IH, sa...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.lb590